MODIFIED IONSPRAY INTERFACE FOR SUPERCRITICAL-FLUID CHROMATOGRAPHY MASS-SPECTROMETRY - INTERFACE DESIGN AND INITIAL RESULTS

被引：18

作者：

PINKSTON, JD ^{[1
]}

BAKER, TR ^{[1
]}

机构：

[1] PROCTER & GAMBLE CO,MIAMI VALLEY LABS,CINCINNATI,OH 45253

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1995年 / 9卷 / 12期

关键词：

D O I：

10.1002/rcm.1290091202

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A pneumatically assisted electrospray liquid chromatography/mass spectrometry interface has been modified for use with open-tubular supercritical fluid chromatography (SPC). The modified interface houses the SFC flow restrictor within the spray device. A sheath-flow liquid of methanal or methanol/water containing ammonium acetate flows coaxially to the restrictor, The addition of the sheath-flow liquid results in the ionization of analytes known to be in a neutral charge state during the chromatographic separation. The sheath-how liquid also allows for the independent operation of the chromatograph and the mass spectrometer. Both could be operated under optimum conditions. The operation of the interface was optimized using a solution of poly(dimethylsiloxane) in CO, introduced by continuous infusion. We also report the application of the modified instrument to samples containing amines and propoxylated alcohols.

引用

页码：1087 / 1094

页数：8

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