HISTOPATHOLOGY OF EXPERIMENTAL SPINAL-CORD TRAUMA - COMPARISON OF TREATMENT WITH TRH, NALOXONE, AND DEXAMETHASONE

被引：12

作者：

AKDEMIR, H ^{[1
]}

PASAOGLU, A ^{[1
]}

OZTURK, F ^{[1
]}

SELCUKLU, A ^{[1
]}

KOC, K ^{[1
]}

KURTSOY, A ^{[1
]}

机构：

[1] ERCIYES UNIV,SCH MED,DEPT PATHOL,KAYSERI 38039,TURKEY

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1992年 / 192卷 / 03期

关键词：

SPINAL CORD INJURY; TRH; NALOXONE; DEXAMETHASONE;

D O I：

10.1007/BF02576273

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The results of treatment with thyrotropin-releasing hormone (TRH), naloxone and dexamethasone treatments albino rats with experimental spinal cord injury were compared. All the animals were made paraplegic by the application clip method of Rivlin and Tator. Treatment was administered i.p. as bolus injections in two doses, at 45 and 120 min after the injury. Animals were allocated randomly to four experimental groups: (1) TRH (0.6 mg per dose), (2) naloxone (0.8 mg per dose), (3) dexamethasone (0.6 mg per dose), and (4) control (saline). TRH-treated rats showed significantly better histopathological scores than either naloxone or dexamethasone-treated ones (Kruskal Wallis: 24.058 P<0.001).

引用

页码：177 / 183

页数：7

共 29 条

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