RECURRENCE OF PHILADELPHIA-CHROMOSOME-POSITIVE LEUKEMIA IN DONOR CELLS AFTER BONE-MARROW TRANSPLANTATION FOR CHRONIC GRANULOCYTIC-LEUKEMIA

被引：25

作者：

MCCANN, SR

LAWLER, M

BACIGALUPO, A

机构：

[1] Departments of Hematology and Genetics, St. James Hospital and Trinity College, Dublin

[2] Ospedale San Martino, Genoa

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 10卷 / 06期

关键词：

CGL; DONOR LEUKEMIA; CYTOGENETIC; PCR; VIRAL ORIGIN;

D O I：

10.3109/10428199309148198

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allogeneic bone marrow transplantation has been shown to be a very effective therapy for Chronic Granulocytic Leukemia with long term disease free survivals in excess of 60%. Relapse rates remain low at 15% following histocompatible sibling transplants and lower rates following matched unrelated donor grafts. Relapse rates however, are higher if BMT is carried out in transformation or blast crisis. Leukemic relapse in donor cells following transplantation for CGL is a rare event. The occurrence of donor leukemia however, may be under reported as accurate and sensitive investigation of the origin of relapsed leukemia following BMT requires DNA based technologies. A possible mechanism of donor leukemia in CGL is transfection of donor cells with the chimeric gene which is unique to this disease. It is possible that the malignant cells found in transformed or blast crisis of CGL may have a greater potential to transfect donor haematopoietic material. Careful evaluation of the incidence of donor leukemia using molecular biology methods may elucidate the frequency of this event following BMT for CGL.

引用

页码：419 / 425

页数：7

共 58 条

[1]

Chao N.J., Forman S.J., Schmidt G.M., Snyder D.S., Amylon M.D., Konrad P.N., Nademanee A.P., O'Don-nell M.R., Parker P.M., Stein A.S., Smith E., Wong R.M., Hoppe R.T., Blume K.G., Allogeneic bone marrow transplantation for high risk acute lymphoblastic leukemia during first complete remission, Blood, 78, pp. 1923-1927, (1991)

[2]

Sanders J.E., Thomas E.D., Buckner E.D., Doney K., Marrow transplantation for children with acute lymphoblastic leukemia in second remission, Blood, 70, pp. 324-326, (1987)

[3]

McGlave P., Bone Marrow transplants in chronic my-elogenous leukemia: an overview of determinants of survival, Semin. Hematol., 27, 3, pp. 23-30, (1990)

[4]

Conde E., Iriondo A., Rayon C., Richard C., Fanjul E., Garijo J., Hermosa V., Coma A., Bello C., Carrera D., Baro J., Zubizaretta A., Allogeneic bone marrow transplantation versus intensive chemotherapy for acute my-elogenous leukemia in first remission: a prospective control trial, Br. J. Haematol., 68, pp. 219-226, (1988)

[5]

Thomas E.D., Clift R.A., Fefer A., Appelbaum F.R., Beatty P., Bensinger W.I., Buckner C.D., Cheever M.A., Deeg H.J., Doney K., Fluornoy N., Greenberg P., Hansen J.A., Martin P., McGuffin R., Ramberg R., Sanders J.E., Singer J., Stewart P., Storb R., Sullivan K., Weiden P.L., Witherspoon R., Marrow transplantation for the treatment of chronic myelogenous leukemia, Ann. Iniern. Med., 104, pp. 155-163, (1986)

[6]

Thomas E.D., Clift R.A., Indications for marrow transplantation in chronic myelogenous leukemia, Blood, 73, pp. 861-864, (1989)

[7]

Seeker Walker L.M., Craig J.M., Hawkins J.M., Hoffbrand A.V., Philadelphia positive acute lympho-cytic leukemia in adults: age distribution, BCR breakpoint and prognostic significance, Leukemia, 5, pp. 196-199, (1991)

[8]

Goldman J.M., Gale R.P., Horowitz M.M., Biggs J.C., Champlin R.E., Gluckman E., Hoffman R.G., Jacobsen S.J., Marmont A.M., McGlave P.B., Messner H.A., Rimm A.A., Rozman C., Speck B., Tura S., Weiner R.S., Bortin M.M., Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: increased risk of relapse associated with T cell depletion, Ann. Intern. Med., 108, pp. 806-814, (1988)

[9]

Horowitz M.M., Gale R.P., Sondel P.M., Goldman J.M., Kersey J., Kolb H.J., Rimm A.A., Ringden O., Rozman C., Speck B., Truitt R.L., Zwann F.E., Bortin M.M., Graft versus leukemia reactions after bone marrow transplantation, Blood, 75, pp. 555-562, (1990)

[10]

Hook E.B., Exclusion of chromosomal mosaicism. tables of 90%, 95% and 99% confidence limits and comments on their use, Am. J. Hum. Genet., 29, pp. 94-97, (1977)

← 1 2 3 4 5 6 →