USE OF SUPPORTS IN LYOPHILIZATION OF OIL-IN-WATER EMULSIONS

被引:24
作者
LLADSER, M
MEDRANO, C
ARANCIBIA, A
机构
[1] Departamento de Farmacia, Facultad de Quimica y Farmacia, Universidad de Chile, Santiago
关键词
D O I
10.1111/j.2042-7158.1968.tb09780.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The results of drying oil‐in‐water emulsions by lyophilization have shown this process could be applied to emulsions having dissolved in the aqueous phase a solid material which acts as support for the oily phase after the water has been removed. The rate of creaming and the globule size distribution were also investigated. The tests were made before and immediately after lyophilization, and after 20 and 40 days of storage at room temperature (18–20°) at 0° ±1° and at 40° ±1°. The emulsions were coarser and creaming rate was increased after lyophilization. 1968 Royal Pharmaceutical Society of Great Britain
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页码:450 / +
页数:1
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