SEPARATION, IDENTIFICATION AND ASSAY OF FLURADOLINE HYDROCHLORIDE IN THE PRESENCE OF OTHER TRICYCLIC ANTIDEPRESSANTS OR NEUROLEPTICS BY SPECTRAL AND THIN-LAYER AND LIQUID-CHROMATOGRAPHIC METHODS

被引：5

作者：

JOSEPHCHARLES, J ^{[1
]}

BERTUCAT, M ^{[1
]}

机构：

[1] UFR SCI PHARMACEUT,CHIM ANALYT APPL LAB,F-33076 BORDEAUX,FRANCE

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 284卷 / 01期

关键词：

FLUOROMETRY; LIQUID CHROMATOGRAPHY; THIN-LAYER CHROMATOGRAPHY; UV-VISIBLE SPECTROPHOTOMETRY; FLURADOLINE HYDROCHLORIDE; PHARMACEUTICALS;

D O I：

10.1016/0003-2670(93)80006-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Fluradoline hydrochloride is a novel centrally acting analgesic with antidepressant activity. Its W absorption and emission spectra and thin-layer and liquid chromatographic (TLC and LC) identification are described. The separation of tricyclic antidepressant or neuroleptic compounds including zotepine, amoxapine, loxapine, fluperlapine, clotiapine, nitroxazepine and fluradoline by TLC and LC is reported. The UV spectrophotometric, spectrofluorimetric and LC methods described can be applied to the determination of fluradoline.

引用

页码：45 / 52

页数：8

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