EFFECTS OF THE NOVEL COMPOUND HOE-065, A CENTRAL ENHANCER OF CHOLINERGIC ACTIVITY, ON VOLUNTARY ALCOHOL-CONSUMPTION IN RATS

Hoe 065 is a compound structurally related to the angiotensin converting enzyme inhibitors and capable of increasing central cholinergic activity. The effects of this compound were studied on alcohol intake and on the reduction in alcohol intake produced by abutapril, an angiotensin converting enzyme inhibitor. Hoe 065 failed to alter alcohol intake or to modify the reduction in alcohol intake produced by abutapril. These findings suggest that enhanced cholinergic activity may not play a role in the control of alcohol consumption and may not be part of the mechanism by which the angiotensin converting enzyme inhibitors reduce alcohol intake.