THE IL-2/IL-2 RECEPTOR SYSTEM - A TARGET FOR RATIONAL IMMUNE INTERVENTION (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 159-164, 1993)

被引：176

作者：

WALDMANN, TA

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 06期

关键词：

D O I：

10.1016/0167-5699(93)90043-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of interleukin 2 (IL-2), induction of its multisubunit receptor and subsequent interplay of this ligand with its receptor are pivotal events in T-cell activation. Our present understanding of the normal IL-2/IL-2R system and of disorders in this network in disease opens the possibility for more specific immune intervention. Thomas Waldmann discusses the clinical application of IL-2, agents that inhibit IL-2 synthesis and action, and how the anti-IL-2 receptor-directed therapy provides a novel perspective for prevention of allograft rejection and for treatment of graft versus host disease, select autoimmune disorders and certain neoplastic diseases.

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页码：264 / 270

页数：7

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