IDENTIFICATION OF A SULFATED TETRASACCHARIDE WITH HEPARIN-LIKE ANTIPROLIFERATIVE ACTIVITY

被引：22

作者：

WESSEL, HP

TSCHOPP, TB

HOSANG, M

IBERG, N

机构：

[1] Pharma Division, Preclinical Research F.HOFFMANN-LA ROCHE LTD CH

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80505-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Investigation of the smooth muscle cell antiproliferative activities of Trestatin A sulfate substructures showed that a sulfated pentasaccharide is required to maintain a heparin-like effect. The modification of one glycosidic bond led to a synthetically readily available tetrasaccharide, namely sulfated beta-maltosyl trehalose 12, with similar antiproliferative but devoid of anticoagulant activity.

引用

页码：1419 / 1422

页数：4

共 21 条

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