CONCISE ENANTIOSELECTIVE SYNTHESIS OF A KEY SYNTHETIC INTERMEDIATE FOR ANTICANCER ANTHRACYCLINES BASED ON THE CHEMISTRY OF 1-TRIMETHYLSILYLBUTA-2,3-DIENE

被引:15
作者
HATAKEYAMA, S [1 ]
SUGAWARA, K [1 ]
TAKANO, S [1 ]
机构
[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN
关键词
D O I
10.1039/c39910001533
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(R)-(-)-2-Acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol 6, a key intermediate for the synthesis of anticancer anthracyclines, has been synthesized enantioselectively in 39% overall yield (8 steps) starting from highly diastereoselective reaction of 1-trimethylsilylbuta-2,3-diene with the chiral acetal 7.
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页码:1533 / 1534
页数:2
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