CONCISE ENANTIOSELECTIVE SYNTHESIS OF A KEY SYNTHETIC INTERMEDIATE FOR ANTICANCER ANTHRACYCLINES BASED ON THE CHEMISTRY OF 1-TRIMETHYLSILYLBUTA-2,3-DIENE

被引：15

作者：

HATAKEYAMA, S ^{[1
]}

SUGAWARA, K ^{[1
]}

TAKANO, S ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 21期

关键词：

D O I：

10.1039/c39910001533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(R)-(-)-2-Acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol 6, a key intermediate for the synthesis of anticancer anthracyclines, has been synthesized enantioselectively in 39% overall yield (8 steps) starting from highly diastereoselective reaction of 1-trimethylsilylbuta-2,3-diene with the chiral acetal 7.

引用

页码：1533 / 1534

页数：2

共 21 条

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