CHITOSAN AS A TABLET BINDER

被引：69

作者：

UPADRASHTA, SM

KATIKANENI, PR

NUESSLE, NO

机构：

[1] School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 15期

关键词：

D O I：

10.3109/03639049209040896

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chitosan was evaluated as a binder for chlorpheniramine maleate tablets in comparison with other cellulose binders such as sodium carboxymethylcellulose, hydroxypropylmethylcellulose and methylcellulose. The effects of binder concentration on the mechanical properties of granules and tablets as well as on disintegration time and dissolution profiles were studied. Results showed that granules prepared with methylcellulose had lowest percentage of fines and friability. Chitosan tablets showed best dissolution profiles. The rank order correlation for binder efficiency was: hydroxypropylmethylcellulose > chitosan > methylcellulose > sodium carboxymethylcellulose.

引用

页码：1701 / 1708

页数：8

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