ORAL-ADMINISTRATION OF IDEBENONE, A STIMULATOR OF NGF SYNTHESIS, RECOVERS REDUCED NGF CONTENT IN AGED RAT-BRAIN

被引：32

作者：

NITTA, A ^{[1
]}

HASEGAWA, T ^{[1
]}

NABESHIMA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,NAGOYA 466,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 163卷 / 02期

关键词：

NERVE GROWTH FACTOR; IDEBENONE; CHOLINE ACETYLTRANSFERASE; SENILE DEMENTIA OF THE ALZHEIMER TYPE; AGED RAT;

D O I：

10.1016/0304-3940(93)90387-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The relationship between nerve growth factor (NGF) and senile dementia of the Alzheimer type is of interest. We demonstrate here that the oral administration of idebenone, a stimulator of NGF synthesis in vitro, produced recovery of reduced NGF content in aged rat brain. Twenty-one-day successive administration of idebenone produced significant recovery of reduced NGF content in the frontal cortex and parietal cortex of aged rats. These results suggest that NGF content in the brain is low in aged rats and that oral administration of idebenone leads to a recovery of this reduction.

引用

页码：219 / 222

页数：4

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