THE TOTAL SYNTHESIS OF SWINHOLIDE-A .1. A STEREOCONTROLLED SYNTHESIS OF A C-19-C-32 SEGMENT

被引：57

作者：

PATERSON, I

CUMMING, JG

WARD, RA

LAMBOLEY, S

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON | 1995年 / 51卷 / 34期

关键词：

D O I：

10.1016/0040-4020(95)00546-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-19-C-32 segment 10 of swinholide A was prepared in 15 steps (8% yield, 82% ds) from (+/-)-16. Key steps include (i) the Sharpless epoxidation, 16 --> 17, (ii) the acetal allylation, 15 --> 23, (iii) the anti aldol addition, 13 + 14 --> 12, and (iv) the alkene hydroboration, 30 --> 31.

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页码：9393 / 9412

页数：20

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