INVITRO BINDING OF A NOVEL DOPAMINE-D(3) RECEPTOR LIGAND - [I-125] TRANS-7-OH-PIPAT-A

被引:21
作者
KUNG, MP [1 ]
KUNG, HF [1 ]
CHUMPRADIT, S [1 ]
FOULON, C [1 ]
机构
[1] UNIV PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19104
关键词
DOPAMINE-D(3) RECEPTOR; LIGAND BINDING; I-125]TRANS-7-OH-PIPAT-A;
D O I
10.1016/0014-2999(93)90839-A
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
An iodinated dopamine D3 receptor ligand, [I-125]trans-7-OH-PIPAT-A-trans-7-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)aminotetralin, was developed. This ligand demonstrated unique high affinity and selectivity toward the dopamine D3 receptor; K(d) = 0.48 nM and B(max) = 240 fmol/mg of protein in rat striatal membrane homogenates.
引用
收藏
页码:165 / 166
页数:2
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