EVIDENCE FOR OPPOSITE STEREOCHEMICAL COURSES FOR THE REACTIONS CATALYZED BY TYPE-I AND TYPE-II DEHYDROQUINASES

被引：33

作者：

SHNEIER, A

HARRIS, J

KLEANTHOUS, C

COGGINS, JR

HAWKINS, AR

ABELL, C

机构：

[1] UNIV CAMBRIDGE, CHEM LAB, LENSFIELD RD, CAMBRIDGE CB2 1EW, ENGLAND

[2] UNIV E ANGLIA, SCH BIOL SCI, NORWICH NR4 7TJ, NORFOLK, ENGLAND

[3] UNIV GLASGOW, DEPT BIOCHEM, GLASGOW G12 8QQ, SCOTLAND

[4] UNIV NEWCASTLE UPON TYNE, SCH MED, DEPT BIOCHEM & GENET, NEWCASTLE UPON TYNE NE2 7HH, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80419-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

There are two distinct types of dehydroquinase which catalyse the dehydration of dehydroquinate 1 to dehydroshikimate 2. Stereochemical studies using deuterated dehydroquinate are described which show that the reaction catalysed by the type II enzyme proceeds with anti stereochemistry, in contrast to the syn elimination catalysed by the type I enzyme.

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页码：1399 / 1402

页数：4

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