SEQUENCES OF THE OXYTETRACYCLINE POLYKETIDE SYNTHASE-ENCODING OTC GENES FROM STREPTOMYCES-RIMOSUS

被引：42

作者：

KIM, ES

BIBB, MJ

BUTLER, MJ

HOPWOOD, DA

SHERMAN, DH

机构：

[1] UNIV MINNESOTA,DEPT MICROBIOL,ST PAUL,MN 55108

[2] UNIV MINNESOTA,INST BIOPROC TECHNOL,GORTNER LAB 240,ST PAUL,MN 55108

[3] JOHN INNES CTR,JOHN INNES INST,NORWICH NR4 7UH,NORFOLK,ENGLAND

[4] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

GENE | 1994年 / 141卷 / 01期

关键词：

ANTIBIOTIC BIOSYNTHESIS; BETA-KETOACYL SYNTHASE; ACYL CARRIER PROTEIN; AMINO-ACID SIMILARITY;

D O I：

10.1016/0378-1119(94)90144-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The complete nucleotide sequences of the Streptomyces rimosus oxytetracycline (oxyTc) polyketide synthase (PKS)-encoding genes (otcY) has been determined, revealing three open reading frames. The deduced amino-acid sequences correspond to the presumed heterodimeric B-ketoacyl synthase and acyl carrier protein found in other type-II (multicomponent) PKS systems that specify construction of acetate-derived polyketide antibiotics.

引用

页码：141 / 142

页数：2

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