ADRENAL-MEDULLA IS INVOLVED IN THE ALDOSTERONE SECRETAGOGUE EFFECT OF SUBSTANCE-P

被引：22

作者：

MAZZOCCHI, G ^{[1
]}

MALENDOWICZ, LK ^{[1
]}

BELLONI, AS ^{[1
]}

NUSSDORFER, GG ^{[1
]}

机构：

[1] UNIV PADUA,DEPT ANAT,I-35121 PADUA,ITALY

来源：

PEPTIDES | 1995年 / 16卷 / 02期

关键词：

SUBSTANCE P; ALDOSTERONE SECRETION; ADRENAL MEDULLA; RAT;

D O I：

10.1016/0196-9781(94)00178-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Substance P (SP) increased aldosterone secretion of rat adrenal slices, but not of isolated zona glomerulosa cells, and this effect was annulled by two specific antagonist of SP (SP-A). Both tissue preparations displayed an aldosterone secretory response to isoprenaline (IF) that was blocked by l-alprenolol (AL). AL reversed the aldosterone response of adrenal slices to IF, SP, or IP plus SP, whereas SP-A only suppressed that to SP. Quarters of adrenocortical autotransplants, which are completely deprived of chromaffin cells, showed an aldosterone response to IF, but not to SP. These findings suggest that the mechanism underlying the aldosterone secretagogue action of SP probably involves the stimulation of catecholamine release by adrenal medulla chromaffin cells..

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页码：351 / 355

页数：5

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