THE ASSOCIATION BETWEEN CELIAC-DISEASE, DERMATITIS-HERPETIFORMIS AND CERTAIN HLA-ANTIGENS IN ICELANDERS

被引：4

作者：

ARNASON, A

SKAFTADOTTIR, I

SIGMUNDSSON, J

MOONEY, E

BJORNSSON, J

CARIGLIA, N

PALSSON, G

GUDJONSSON, H

机构：

[1] UNIV ICELAND,DEPT PATHOL,IMMUNOGENET UNIT,IS-101 REYKJAVIK,ICELAND

[2] DIST HOSP,AKUREYRI,ICELAND

[3] UNIV HOSP ICELAND,DEPT MED,REYKJAVIK,ICELAND

[4] UNIV HOSP ICELAND,DEPT PAEDIAT,REYKJAVIK,ICELAND

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1994年 / 21卷 / 06期

关键词：

D O I：

10.1111/j.1744-313X.1994.tb00218.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Twenty-eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland, Standard serological techniques were used for HLA typing. Twenty-five individuals with CD were typed, 21 (84%) of whom carried DR3,DQ2. Twelve of these 25 (48%) had DR3,DR7, DQ2, which makes them possibly homozygous for DQ2, and suggests that homozygosity of DQ2 increases the risk for CD. The four DH patients that were typed all had HLA-B8,DR3,DQ2. It is concluded that CD and DH are associated with DR3, DQZ in Icelanders.

引用

页码：457 / 460

页数：4

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