ANALOGS OF TETRAHYDROFOLIC ACID .18. ON MODE OF BINDING OF SOME 6-ARYL- AND 6-ARALKYLPYRIMIDINES TO FOLIC REDUCTASE

被引：9

作者：

BAKER, BR

SHAPIRO, HS

WERKHEISER, WC

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1965年 / 8卷 / 03期

关键词：

D O I：

10.1021/jm00327a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：283 / +

页数：1

相关论文

共 15 条

[1] ANALOGS OF TETRAHYDROFOLIC ACID .7. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE [J].

BAKER, BR ;

MORREAL, CE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) :840-&

[2] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SANTI, DV ;

ALMAULA, PI ;

WERKHEISER, WC .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :24-&

[3] ANALOGS OF TETRAHYDROFOLIC ACID .8. SYNTHESIS OF N-[1-(2-AMINO-4-MERCAPTO-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A MERCAPTO ANALOG [J].

BAKER, BR ;

HO, BT ;

MORREAL, CE .

JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (06) :658-&

[4] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .15. MODE OF BINDING OF 2,4-DIAMINOPYRIMIDINES TO FOLIC REDUCTASE + THYMIDYLATE SYNTHETASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (12) :1457-&

[6] ANALOGS OF TETRAHYDROFOLIC ACID .19. ON MODE OF BINDING OF PYRIMIDYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPIONYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE [J].

BAKER, BR ;

ALMAULA, PI .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1964, 1 (05) :263-&

[7] ANALOGS OF TETRAHYDROFOLIC ACID .17. ON MODE OF BINDING OF P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (01) :35-&

[8] ANALOGS OF TETRAHYDROFOLIC ACID .24. FACILE SYNTHETIC ROUTE TO 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE + THYMIDYLATE SYNTHETASE INHIBITOR [J].

BAKER, BR ;

SANTI, DV ;

SHAPIRO, HS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (11) :1317-&

[9] STRUCTURE OF WATER AND HYDROPHOBIC BONDING IN PROTEINS .3. THERMODYNAMIC PROPERTIES OF HYDROPHOBIC BONDS IN PROTEINS [J].

NEMETHY, G ;

SCHERAGA, HA .

JOURNAL OF PHYSICAL CHEMISTRY, 1962, 66 (10) :1773-+

[10]

SISTARE J, 1954, CA 2055H, V48