REDUCED ADHERENCE AND INHIBITION OF HYPHAL DEVELOPMENT OF CANDIDA-ALBICANS BY THE ANTIMICROBIAL AGENT POLYNOXYLIN

被引：5

作者：

GORMAN, SP

MCCAFFERTY, DF

WOOLFSON, AD

KENNEDY, GE

机构：

[1] Department of Pharmacy, Medical Biology Centre, The Queen's University of Belfast, Belfast,BT9 7BL, United Kingdom

来源：

LETTERS IN APPLIED MICROBIOLOGY | 1988年 / 6卷 / 06期

关键词：

D O I：

10.1111/j.1472-765X.1988.tb01235.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polynoxyhn (Anaflex R ) was investigated for antimicrobial activities ancillary to its known cidal and static effects. Significant reductions in adherence of Candida albicans blastospores (oral strain) to human buccal epithelial cells were observed following polynoxylin treatment. The anti-adherence activity was concentration and time-dependent. Treatment of the epithelial cells did not result in significant reductions in adherence. Polynoxylin was also shown to inhibit the germination and hyphal development of C. albicans. © 1988 Oxford University Press. All rights reserved.

引用

页码：145 / 148

页数：4

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