THE FORMATION OF KETONES BY A REACTION EQUIVALENT TO R-+R'COCH2+-]R'COCH2R

被引：8

作者：

KATRITZKY, AR

WROBEL, L

SAVAGE, GP

DEYRUPDREWNIAK, M

机构：

[1] Department of Chemistry, University of Florida, Gainesville, FL

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 01期

关键词：

D O I：

10.1071/CH9900133

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general method has been developed for the overall transformation of a-bromo ketones to a-alkyl or a-aryl ketones, with benzotriazole being used as a synthetic auxiliary, a- Benzotriazolyl ketones, when converted into their phenylhydrazones, reacted smoothly with alkyl and aryl Grignard reagents, which displaced benzotriazolate, to give the corresponding a-alkyl or a-aryl hydrazones. In some cases, these hydrolysed directly to the a-alkyl or a-aryl ketones. In each case, the product was treated with 2, 4-dinitrophenylhydrazine to isolate the target ketones as the corresponding 2, 4-dinitrophenylhydrazones. © 1990 ASEG.

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页码：133 / 139

页数：7

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