METABOLITES OF LACHNELLULA-FUSCOSANGUINEA (REHM) .1. THE ISOLATION, STRUCTURE DETERMINATION, AND SYNTHESIS OF LACHNELLULOIC ACID

被引：19

作者：

AYER, WA ^{[1
]}

VILLAR, JDF ^{[1
]}

机构：

[1] UNIV ALBERTA, DEPT CHEM, EDMONTON T6G 2G2, ALBERTA, CANADA

来源：

CANADIAN JOURNAL OF CHEMISTRY | 1985年 / 63卷 / 06期

关键词：

D O I：

10.1139/v85-197

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The metabolites produced in liquid culture by the fungus L. fuscosanguinea (Rehm) Dennis have been examined and 2 antifungal agents, lachnelluloic acid and lachnellulone, have been isolated. The structure of lachnelluloic acid has been established as (-)-4-hydroxy-3-octanoyl-6-pentyl-5,6-dihydro-2-pyrone by chemical and spectroscopic methods. The total synthesis of racemic lachnelluloic acid, starting from 6,8-tridecanedione is reported. Lachnelluloic acid shows strong antifungal activity against Ceratocystis ulmi, the causative agent of Dutch elm disease.

引用

页码：1161 / 1165

页数：5

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