DOPAMINERGIC MECHANISM OF IMIPRAMINE ACTION IN AN ANIMAL-MODEL OF DEPRESSION

被引：108

作者：

MUSCAT, R ^{[1
]}

SAMPSON, D ^{[1
]}

WILLNER, P ^{[1
]}

机构：

[1] CITY LONDON POLYTECH, DEPT PSYCHOL, CALCUTTA HOUSE, OLD CASTLE ST, LONDON EI 7NT, ENGLAND

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 28卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-3223(90)90577-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats, subjected chronically (10-12 weeks) to a variety of mild, unpredictable stressors, showed a decrease in their consumption of weak sucrose solution; normal behavior was restored by chronic (5-9 weeks) treatment with the tricyclic antidepressant imipramine. Acute administration of the dopamine receptor antagonist pimozide or the specific dopamine D2 receptor antagonist raclopride had no effect in nonstressed animals and in vehicle-treated stressed animals, but both drugs selectively reversed the improvement of performance in imipramine-treated stressed animals. The 5HT antagonist metergoline increased sucrose consumption in all groups. The data suggest that the mechanism of action of imipramine in this model is an increase in functional activity at dopamine (DA) synapses. © 1990.

引用

页码：223 / 230

页数：8

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