WILSONS-DISEASE - DEVELOPMENT OF NEUROLOGICAL DISEASE AFTER BEGINNING PENICILLAMINE THERAPY

被引:37
作者
GLASS, JD
REICH, SG
DELONG, MR
机构
[1] Department of Neurology, The Johns Hopkins Hospital, Baltimore, Md
关键词
D O I
10.1001/archneur.1990.00530050119022
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Patients with neurological symptoms and signs of Wilson's disease have been frequently noted to have a worsening of their condition after beginning chelation therapy with d-penicillamine. Presymptomatic patients, however, are not expected to develop neurological manifestations once appropriate therapy is begun. We describe a patient who was seen with hepatic disease and no neurological symptoms who became neurologically incapacitated soon after beginning penicillamine therapy. This case identifies an unexpected complication of penicillamine therapy that should be watched for in the presymptomatic patient who is beginning therapy. © 1990, American Medical Association. All rights reserved.
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页码:595 / 596
页数:2
相关论文
共 13 条
[1]   WORSENING OF NEUROLOGIC SYNDROME IN PATIENTS WITH WILSONS-DISEASE WITH INITIAL PENICILLAMINE THERAPY [J].
BREWER, GJ ;
TERRY, CA ;
AISEN, AM ;
HILL, GM .
ARCHIVES OF NEUROLOGY, 1987, 44 (05) :490-493
[2]   TREATMENT OF WILSONS-DISEASE [J].
BREWER, GJ ;
YUZBASIYANGURKAN, V ;
YOUNG, AB .
SEMINARS IN NEUROLOGY, 1987, 7 (02) :209-220
[3]   LONG-TERM THERAPY OF WILSONS DISEASE [J].
DEISS, A ;
LYNCH, RE ;
LEE, GR ;
CARTWRIGHT, GE .
ANNALS OF INTERNAL MEDICINE, 1971, 75 (01) :57-+
[4]   COMPUTED-TOMOGRAPHY IN WILSON DISEASE [J].
HARIK, SI ;
POST, MJD .
NEUROLOGY, 1981, 31 (01) :107-110
[5]   WILSONS-DISEASE CLINICAL CORRELATION WITH CRANIAL COMPUTED-TOMOGRAPHY [J].
KENDALL, BE ;
POLLOCK, SS ;
BASS, NM ;
VALENTINE, AR .
NEURORADIOLOGY, 1981, 22 (01) :1-5
[6]  
SASSKORTSAK A, 1975, PEDIATR CLIN N AM, V22, P963
[7]  
SHEINBERG IH, 1984, WILSONS DISEASE MAJO, P23
[8]   CLINICAL-ASSESSMENT OF 31 PATIENTS WITH WILSONS-DISEASE - CORRELATIONS WITH STRUCTURAL-CHANGES ON MAGNETIC-RESONANCE-IMAGING [J].
STAROSTARUBINSTEIN, S ;
YOUNG, AB ;
KLUIN, K ;
HILL, G ;
AISEN, AM ;
GABRIELSEN, T ;
BREWER, GJ .
ARCHIVES OF NEUROLOGY, 1987, 44 (04) :365-370
[9]   PREVENTION OF WILSONS DISEASE IN ASYMPTOMATIC PATIENTS [J].
STERNLIEB, I ;
SCHEINBERG, IH .
NEW ENGLAND JOURNAL OF MEDICINE, 1968, 278 (07) :352-+
[10]  
STERNLIEB I, 1976, DIS LIVER BILIARY TR, P137