A CONVENIENT SYNTHESIS OF [3-H-3]SQUALENE AND [3-H-3]-2,3-OXIDOSQUALENE

被引:9
作者
CERUTI, M
GROSA, G
ROCCO, F
DOSIO, F
CATTEL, L
机构
[1] Istituto di Chimica Farmaceutica Applicata, Facoltà di Farmacia, Torino, 10125
关键词
SQUALENE EPOXIDASE; OXIDOSQUALENE CYCLASE; TRITIUM LABELING; CHOLESTEROL BIOSYNTHESIS; ENZYME ASSAY;
D O I
10.1002/jlcr.2580340613
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
[3-H-3]Squalene and [3-H-3]-2,3-oxidosqualene, key compounds for studying the biosynthesis of sterols, were synthesized. The main step was a modified Wittig reaction of [1-H-3]trisnorsqualene aldehyde with a phosphorus ylide to give [3-H-3]squalene or with a sulfur ylide to give [3-H-3]-2,3-oxidosqualene. These compounds were obtained in high radiochemical yield and high purity under simple conditions.
引用
收藏
页码:577 / 585
页数:9
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