PARTITION-COEFFICIENTS IN A LIPOSOME WATER-SYSTEM - METHODS FOR DETERMINATION AND ERROR ANALYSIS

The Grunbauer's method using multiple-regression analysis has been applied to determine the partition coefficients in liposome/water systems after a modification to an ideal case without a constant term in the regression equation. Further, an error analysis was achieved for the partition coefficients with the aid of a non-parametric bootstrap method. The partition coefficients of the substituted hyroxybenzyl alcohols were measured in systems of liposome/water, olive oil/water, and 1-octanol/water. A quantitative structure-activity relationships analyses using these partition coefficients are compared and discussed.