AS-183, A NOVEL INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY SCEDOSPORIUM SP SPC-15549

被引：24

作者：

KURODA, K

YOSHIDA, M

UOSAKI, Y

ANDO, K

KAWAMOTO, I

OISHI, E

ONUMA, H

YAMADA, K

MATSUDA, Y

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,3-6-6 ASAHIMACHI,MACHIDA,TOKYO 194,JAPAN

[2] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,NAGAIZUMI,SHIZUOKA 411,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 08期

关键词：

D O I：

10.7164/antibiotics.46.1196

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel compound, AS-183, which inhibits acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from the culture broth of a fungus, Scedosporium sp. SPC-15549. AS-183 inhibited ACAT activity in an enzyme assay system using rabbit liver microsomes with an IC50 value of 0.94 muM. AS-183 also inhibited cholesterol ester formation in HepG2, CaCo2, and THP-1 cells with IC50 values of 18.1, 25.5, and 34.5 muM, respectively.

引用

页码：1196 / 1202

页数：7

共 13 条

[1] PROPERTIES OF ACYL-COA-CHOLESTEROL O-ACYLTRANSFERASE IN AORTIC MICROSOMES FROM ATHEROSCLEROTIC RABBITS [J].