IMMUNOLOCALIZATION OF BMP-6, A NOVEL TGF-BETA-RELATED CYTOKINE, IN NORMAL AND ATHEROSCLEROTIC SMOOTH-MUSCLE CELLS

被引：49

作者：

SCHLUESENER, HJ

MEYERMANN, R

机构：

[1] Institute of Brain Research, University of Tübingen, D-72076 Tübingen

来源：

ATHEROSCLEROSIS | 1995年 / 113卷 / 02期

关键词：

BMP-6; TGF-BETA; ATHEROSCLEROSIS; ARTERIAL SMOOTH MUSCLE CELL;

D O I：

10.1016/0021-9150(94)05438-O

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have analyzed expression of a novel transforming growth factor type beta (TGF-beta)-related cytokine, bone morphogenetic protein-6 (BMP-6) in normal and atherosclerotic brain arteries. BMP-6 immunoreactivity was detected in smooth muscle cells of normal cerebral blood vessels. It is also expressed by smooth muscle cells of intimal plaques in atherosclerotically changed blood vessels. The BMPs regulate tissue modeling and remodeling and aberrant expression of BMPs might contribute to smooth muscle cell migration, proliferation, tissue reorganization and macrophage attraction, which are known mechanisms of atherosclerotic plaque formation.

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页码：153 / 156

页数：4

相关论文

共 18 条

[1] BONE MORPHOGENETIC PROTEIN EXPRESSION IN HUMAN ATHEROSCLEROTIC LESIONS [J].

BOSTROM, K ;

WATSON, KE ;

HORN, S ;

WORTHAM, C ;

HERMAN, IM ;

DEMER, LL .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1800-1809

[2] OSTEOGENIN AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2B ARE CHEMOTACTIC FOR HUMAN MONOCYTES AND STIMULATE TRANSFORMING GROWTH FACTOR-BETA-1 MESSENGER-RNA EXPRESSION [J].

CUNNINGHAM, NS ;

PARALKAR, V ;

REDDI, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11740-11744

[3]

HIROTA S, 1993, AM J PATHOL, V143, P1003

[4]

JONES CM, 1991, DEVELOPMENT, V111, P531

[5] SYNERGISTIC ACTION OF ANGIOTENSIN-II, INSULIN-LIKE GROWTH FACTOR-I, AND TRANSFORMING GROWTH-FACTOR-BETA ON PLATELET-DERIVED GROWTH FACTOR-BB, BASIC FIBROBLASTIC GROWTH-FACTOR, AND EPIDERMAL GROWTH FACTOR-INDUCED DNA-SYNTHESIS IN VASCULAR SMOOTH-MUSCLE CELLS [J].

KO, Y ;

STIEBLER, H ;

NICKENIG, G ;

WIECZOREK, AJ ;

VETTER, H ;

SACHINIDIS, A .

AMERICAN JOURNAL OF HYPERTENSION, 1993, 6 (06) :496-499

[6] MODULATION OF GROWTH OF VASCULAR SMOOTH-MUSCLE CELLS BY ACTIVIN-A [J].

KOJIMA, I ;

MOGAMI, H ;

KAWAMURA, N ;

YASUDA, H ;

SHIBATA, H .

EXPERIMENTAL CELL RESEARCH, 1993, 206 (01) :152-156

[7]

KOK LP, 1992, MICROWAVE COOKBOOK M

[8] VGR-1, A MAMMALIAN GENE RELATED TO XENOPUS VG-1, IS A MEMBER OF THE TRANSFORMING GROWTH FACTOR-BETA GENE SUPERFAMILY [J].

LYONS, K ;

GRAYCAR, JL ;

LEE, A ;

HASHMI, S ;

LINDQUIST, PB ;

CHEN, EY ;

HOGAN, BLM ;

DERYNCK, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4554-4558

[9] PATTERNS OF EXPRESSION OF MURINE VGR-1 AND BMP-2A RNA SUGGEST THAT TRANSFORMING GROWTH FACTOR-BETA-LIKE GENES COORDINATELY REGULATE ASPECTS OF EMBRYONIC-DEVELOPMENT [J].

LYONS, KM ;

PELTON, RW ;

HOGAN, BLM .

GENES & DEVELOPMENT, 1989, 3 (11) :1657-1668

[10] TRANSFORMING GROWTH-FACTOR BETA-1-MEDIATED INHIBITION OF SMOOTH-MUSCLE CELL-PROLIFERATION IS ASSOCIATED WITH A LATE G1 CELL-CYCLE ARREST [J].

REDDY, KB ;

HOWE, PH .

JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 156 (01) :48-55