VARIATIONS OF NUCLEOTIDE-SEQUENCES AND TRANSCRIPTION OF THE SH GENE AMONG MUMPS-VIRUS STRAINS

被引：53

作者：

TAKEUCHI, K

TANABAYASHI, K

HISHIYAMA, M

YAMADA, A

SUGIURA, A

机构：

[1] Department of Measles Virus, National Institute of Health, Musashimurayama, Tokyo, 190-12

来源：

VIROLOGY | 1991年 / 181卷 / 01期

关键词：

D O I：

10.1016/0042-6822(91)90504-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have compared nucleotide sequences of the SH genes as well as their flanking regions of six mumps virus strains and found a high amino acid diversity (up to 23%) of the putative SH proteins among these strains. It was found, in addition, that one of these strains (Enders strain) contained a point mutation in putative polyadenylation signal for the F gene mRNA (TTTAGAAAAAAA to TTTAGAAGAAAA ). Northern blot analysis showed that the Enders strain was also unique in that neither monocistronic SH nor bicistronic SH-HN mRNA could be detected in the cells infected with this particular strain. © 1991.

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页码：364 / 366

页数：3

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