HOW WE DESCRIBE COMPETITIVE ANTAGONISTS - 3 QUESTIONS OF USAGE

被引：60

作者：

JENKINSON, DH

机构：

[1] University College London, London, WC1E 6BT, Gower Street

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0165-6147(91)90497-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Competitive antagonists are used by pharmacologists in a definitive manner in the identification of receptor subtypes. However, despite the many decades of their use, there is still some confusion over terms and terminology. Don Jenkinson, a member of the IUPHAR Committee on Receptor Nomenclature, points to terms that are often used imprecisely: pA2 is frequently used interchangeably, but erroneously, for log K(B); the term 'competitive' itself has been used ambiguously, and it is even possible that confusion can arise by the expression of the constant from the Schild equation in different ways (affinity/equilibrium/dissociation constants).

引用

页码：53 / 54

页数：2