ORAL TOLERANCE THERAPY IN AUTOIMMUNE-DISEASE

被引：2

作者：

HURST, SD ^{[1
]}

NICHOLSON, SM ^{[1
]}

BARRETT, TA ^{[1
]}

机构：

[1] NORTHWESTERN UNIV,SCH MED,SCH MED,GASTROENTEROL SECT,303 E CHICAGO AVE,CHICAGO,IL 60611

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 1993年 / 9卷 / 06期

关键词：

D O I：

10.1097/00001574-199309060-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Results from a recent clinical trial have suggested that the feeding of autoantigenic proteins may be an effective therapy for autoimmune diseases (Weiner et al., Science 1993, 259:1321-1326). This treatment, called oral tolerance therapy, proposes to inhibit aberrant immune responses by producing immune ''acceptance'' or tolerance to target tissue proteins. Because of the innovative nature of this approach, interest has been focused on the regulatory mechanisms that produce the state of oral tolerance. In this review, we address the models of oral tolerance and suggest that this state may involve unique regulatory mechanisms based on the amount of fed protein antigen.

引用

页码：981 / 985

页数：5