ALCOHOL, NITRIC-OXIDE, AND NEUROTOXICITY - IS THERE A CONNECTION - A REVIEW

被引：66

作者：

LANCASTER, FE

机构：

[1] Division of Basic Research, Neuroscience and Behavioral Research Branch, National Institute on Alcohol Abuse and Alcoholism, Mental Health Administration, Rockville, Maryland

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1992年 / 16卷 / 03期

关键词：

NEUROTOXICITY; NITRIC OXIDE; ALCOHOL; EXCITOTOXICITY; GLUTAMATE;

D O I：

10.1111/j.1530-0277.1992.tb01413.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

A hypothesis is presented to explain the influence of alcohol on glutamate generated excitotoxicity. Chronic alcohol exposure is reported to increase glutamate-N-methyl-D-aspartate (NMDA) receptors and calcium ion channel activity, resulting in the neurotoxicity and seizure activity associated with alcohol withdrawal in certain persons. Recent information indicates that nitric oxide is responsible for the neurotoxicity associated with excessive glutamate stimulation of NMDA receptors. Thus, it is hypothesized that nitric oxide is involved in producing the neurotoxicity and cell disturbances associated with chronic alcohol exposure.

引用

页码：539 / 541

页数：3

共 53 条

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