CELL-CYCLE KINETICS ANALYSIS OF HELA-CELLS EXPOSED TO APHIDICOLIN - COMPUTER-SIMULATION

被引：3

作者：

ABED, SY

ELASSOULI, SM

OZKUL, OS

ALIDRISI, M

AMER, M

机构：

[1] KING ABDULAZIZ UNIV, FAC MED, DEPT MED BIOL, JEDDAH, SAUDI ARABIA

[2] KING FAISAL SPECIALIST HOSP & RES CTR, DEPT ONCOL, RIYADH 11211, SAUDI ARABIA

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1992年 / 22卷 / 04期

关键词：

CELL CYCLE; SIMULATION; SYNCHRONIZATION; HELA CELLS; APHIDICOLIN;

D O I：

10.1016/0010-4825(92)90066-V

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Nov et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G1/S boundary and that recruitment and synchrony occurred.

引用

页码：269 / 275

页数：7

共 19 条

[1]

ABED S, 1992, UNPUB DESIGN PHILOS

[2]

ABED S, 1991, SUM P COMP SIM C, P658

[3] POPULATION-DYNAMICAL MODEL OF CELL-DENSITY DEPENDENT GROWTH-REGULATION AND AGING OF FIBROBLASTS INVITRO [J].