Gadolinium and dysprosium chelates of DTPA-amide-dextran: Synthesis, H-1 NMR relaxivity, and induced Na-23 NMR shift

被引：13

作者：

Chu, WJ ^{[1
]}

Elgavish, GA ^{[1
]}

机构：

[1] UNIV ALABAMA,DEPT MED,DIV CARDIOVASC DIS,BIRMINGHAM,AL 35294

来源：

NMR IN BIOMEDICINE | 1995年 / 8卷 / 04期

关键词：

D O I：

10.1002/nbm.1940080404

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In this study the conjugated macromolecular ligand, diethylenetriaminepentaacetic acid (DTPA)-amide-dextran, was synthesized by attaching DTPA to the dextran macromolecule (M(r) similar to 6000) by a covalent amide bond, Subsequently, DTPA-amide-dextran was complexed with either of the two lanthanide metal ions dysprosium (Dy) or gadolinium (Gd), The paramagnetic Na-21 NMR shift induced by Dy(DTPA-amide-dextran) and the relaxivity (rho(1)) induced by Gd(DTPA-amide-dextran) were characterized. Dy(DTPA-amide-dextran) induced a 25% larger Na-21 NMR shift than that induced by Dy(DTPA). Neither the shift induced by Dy(DTPA-amide-dextran) nor the shift induced by Dy(DTPA) was affected by increasing levels of calcium ions in the solution, Gd(DTPA-amide-dextran) exhibited an in vitro rho(1) of 8.4 (mM s)(-1) at a 0.23 T magnetic field and 9.3 (mM s)(-1) at a 0.47 T magnetic field, thus indicating a positive magnetic field dependence.

引用

页码：159 / 163

页数：5

共 14 条

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