ACID ACTIVATION OF (H+-K+)-ATPASE INHIBITING 2-(2-PYRIDYLMETHYL-SULPHINYL)BENZIMIDAZOLES - ISOLATION AND CHARACTERIZATION OF THE THIOPHILIC ACTIVE PRINCIPLE AND ITS REACTIONS

被引:57
作者
FIGALA, V [1 ]
KLEMM, K [1 ]
KOHL, B [1 ]
KRUGER, U [1 ]
RAINER, G [1 ]
SCHAEFER, H [1 ]
SENNBILFINGER, J [1 ]
STURM, E [1 ]
机构
[1] BYK GULDEN LOMBERG CHEM FABR GMBH,KONSTANZ,FED REP GER
关键词
D O I
10.1039/c39860000125
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:125 / 127
页数:3
相关论文
共 9 条
[1]  
BOYD GV, 1966, TETRAHEDRON LETT, V29, P3369
[2]   STRUCTURE ACTIVITY RELATIONSHIPS OF SUBSTITUTED BENZIMIDAZOLES [J].
BRANDSTROM, A ;
LINDBERG, P ;
JUNGGREN, U .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1985, 20 :15-22
[3]  
BRANDSTROM A, 1984, 8 INT S MED CHEM UPP
[4]   K+-STIMULATED ATPASE IN PURIFIED MICROSOMES OF BULLFROG OXYNTIC CELLS [J].
GANSER, AL ;
FORTE, JG .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 307 (01) :169-180
[5]  
IM WB, 1985, J BIOL CHEM, V260, P4591
[6]  
JUNGGREN U, Patent No. 5129
[7]   2-((2-PYRIDYLMETHYL)SULFINYL)BENZIMIDAZOLES - ACID SENSITIVE SUICIDE INHIBITORS OF THE PROTON TRANSPORT-SYSTEM IN THE PARIETAL-CELL [J].
RACKUR, G ;
BICKEL, M ;
FEHLHABER, HW ;
HERLING, A ;
HITZEL, V ;
LANG, HJ ;
ROSNER, M ;
WEYER, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (01) :477-484
[8]   EVIDENCE FOR ACID-INDUCED TRANSFORMATION OF OMEPRAZOLE INTO AN ACTIVE INHIBITOR OF (H+ + K+)-ATPASE WITHIN THE PARIETAL-CELL [J].
WALLMARK, B ;
BRANDSTROM, A ;
LARSSON, H .
BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 778 (03) :549-558
[9]  
3240248