NMR CHARACTERIZATION OF ERODIBLE COPOLYMERS

NMR spectroscopy analysis coupled with information from X-ray diffraction allowed understanding of the nature of the erosion phenomena for degradable polymers. The determination of copolymer composition and comonomer sequence distributions in anhydride copolymers of aliphatic and aromatic dicarboxylic acids is discussed. From high-field nuclear magnetic resonance spectroscopy data the copolymers' sequence was determined. In addition, the characterization of molecular weight distributions by intrinsic viscosity measurements and by gel permeation chromatography (GPC) using the universal calibration procedure was made.