BIOSYNTHESIS OF GLYCOPHOSPHOINOSITOL ANCHORS IN SACCHAROMYCES-CEREVISIAE

被引:11
作者
CONZELMANN, A [1 ]
FANKHAUSER, C [1 ]
PUOTI, A [1 ]
DESPONDS, C [1 ]
机构
[1] UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND
关键词
D O I
10.1016/0309-1651(91)90038-K
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Numerous membrane glycoproteins of Saccharomyces cerevisiae are posttranslationally modified by the addition of a glycophosphatidylinositol (GPI). These proteins can be detected most easily by metabolic labelling of yeast cells with 3H-myoinositol or 3H-palmitate. This report summarizes what little is known about the identity, biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae as well as what could be learned from the system with respect to the biosynthesis of GPI's in general. © 1991.
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页码:863 / 873
页数:11
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