TREATMENT OF OPEN-ANGLE GLAUCOMA AND ISCHEMIC RETINOPATHY WITH DOPAMINE ANTAGONISTS

被引：15

作者：

CHIOU, GCY

机构：

[1] Department of Medical Pharmacology and Toxicology, Texas A&M University Health Science Center, Texas, College Station

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 01期

关键词：

D O I：

10.1089/jop.1994.10.371

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Ocular blood flow in the retina, choroid and optic nerve head should be measured in addition to the intraocular pressure (IOP) in order to better diagnose glaucoma disease and to better evaluate the efficacy of antiglaucoma drugs. It was found that beta-adrenergic blockers, the most widely used antiglaucoma drugs, reduced ocular blood flow in animals and worsened glaucoma disease in some patients, even though the IOP was reduced to the normal range. Therefore, their use for glaucoma treatment requires careful re-evaluation. On the other hand, most dopamine antagonists were found to reduce the IOP and increase the blood flow to the retina, choroid, iris and ciliary muscle. Therefore, these agents could be used for glaucoma treatment. Further, dopamine antagonists were found to improve retinal function after ischemia and, thus, also could be used for the treatment of ischemic retinopathy.

引用

页码：371 / 377

页数：7

共 27 条

[1]

Lierman T.L., Building a Healthy America, pp. 115-119, (1987)

[2]

McLaughlin M.S., Chiou G.C.Y., Synopsis of recent developments in antiglaucoma drugs, J. Ocular Pharmacol., 1, pp. 101-122, (1985)

[3]

Chandler P.A., Grant W.M., Glaucoma, pp. 77-110, (1979)

[4]

Shields M.B., Textbook of Glaucoma, pp. 45-70, (1982)

[5]

Demailly P.H., Aubrier G., Abadie P., Timolol et pronostic fonctionnel perimetrique du glaucome primitif a angle ouvert, J. Fr. Ophthalmol., 8, pp. 383-388, (1985)

[6]

Demmler N., Mueller-Bardorff G., Zunahme von Gesichtsfelddefekten unter Timolol-Langzeitbehandlung bei Patienten mit Weitwinkelglaukom Beobachtung in der augenarztlichen Praxis, Klin. Monatsbl. Sugenheilkd., 183, pp. 53-58, (1983)

[7]

Nielsen N.V., Eriksen J.S., Timolol in maintenance treatment of ocular hypertension and glaucoma, Acta Ophthalmol., 57, pp. 1070-1077, (1979)

[8]

Chiou G.C.Y., Treatment of ocular hypertension and glaucoma with dopamine antagonists, Ophth. Res., 16, pp. 129-134, (1984)

[9]

Chiou G.C.Y., Reduction of intraocular pressure by domperidone, J. Ocular Pharmacol., 2, pp. 131-138, (1986)

[10]

Chiou G.C.Y., Ocular hypotensive action of haloperidol, a dopaminergic antagonist, Arch. Ophthalmol., 102, pp. 143-145, (1984)

← 1 2 3 →