EXCITATORY AMINO-ACIDS AND THE ACTIONS OF COCAINE

被引：72

作者：

KARLER, R

CALDER, LD

机构：

[1] Department of Pharmacology, University of Utah School of Medicine, Salt Lake City

来源：

BRAIN RESEARCH | 1992年 / 582卷 / 01期

关键词：

COCAINE; EXCITATORY AMINO ACID; GLUTAMATE; N-METHYL-D-ASPARTATE; DOPAMINE; CONVULSION; ANIMAL;

D O I：

10.1016/0006-8993(92)90329-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Antagonists of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are an integral component in the reaction sequences involved in the expression of several behavioral effects of cocaine.

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页码：143 / 146

页数：4

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