TREMOR AND ZITTER, CAUSATIVE MUTANT-GENES FOR EPILEPSY WITH SPONGIFORM ENCEPHALOPATHY IN SPONTANEOUSLY EPILEPTIC RAT (SER), ARE TIGHTLY LINKED TO SYNAPTOBREVIN-2 AND PRION PROTEIN GENES, RESPECTIVELY

被引：25

作者：

KURAMOTO, T ^{[1
]}

MORI, M ^{[1
]}

YAMADA, J ^{[1
]}

SERIKAWA, T ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,INST LAB ANIM,SAKYO KU,KYOTO 60601,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1573

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneously epileptic rat (SER) is a homozygote for both tremor (tm) and zitter (zi) genes and exhibits epilepsy-like seizures and spongiform encephalopathy. Genetic linkage analyses revealed that the tm and zi loci were tightly linked to the synaptobrevin-2 (Syb2) on chromosome 10 and the prion protein (Prnp) on chromosome 3, respectively. The genomic DNA sequences of Syb2 of the tm/tm (TRM) rats and exon 2 of the Prnp of the zi/zi (ZI) rats were identical to those of a control rat strain WTC. In addition, no difference was detected for expression of the Syb2 and Prnp on the Northern blot analyses of TRM, ZI and WTC brain, suggesting that the Syb2 and Prnp genes are not the tm and zi, respectively. The assignments of tm and zi to rat chromosome 10q24 and 3q35, however, will be the first step towards the positional cloning of the genes. (C) 1994 Academic Press, Inc.

引用

页码：1161 / 1168

页数：8

共 27 条

[1]

ELFERINK LA, 1989, J BIOL CHEM, V264, P11061

[2] GENES AND EPILEPSY [J].

GARDINER, RM .

JOURNAL OF MEDICAL GENETICS, 1990, 27 (09) :537-544

[3]

GOMI H, 1994, IN PRESS NEUROSCI LE

[4] SPONTANEOUS NEURODEGENERATION IN TRANSGENIC MICE WITH MUTANT PRION PROTEIN [J].

HSIAO, KK ;

SCOTT, M ;

FOSTER, D ;

GROTH, DF ;

DEARMOND, SJ ;

PRUSINER, SB .

SCIENCE, 1990, 250 (4987) :1587-1590

[5] THE SPONTANEOUSLY EPILEPTIC RAT (SER), A ZITTER-STAR TREMOR DOUBLE MUTANT RAT - HISTOPATHOLOGICAL FINDINGS IN THE CENTRAL-NERVOUS-SYSTEM [J].

INUI, T ;

YAMAMURA, T ;

YUASA, H ;

KAWAI, Y ;

OKANIWA, A ;

SERIKAWA, T ;

YAMADA, J .

BRAIN RESEARCH, 1990, 517 (1-2) :123-133

[6] CNS PATHOLOGY IN THE NEUROLOGICAL MUTANT RATS ZITTER, TREMOR AND ZITTER-TREMOR DOUBLE MUTANT (SPONTANEOUSLY EPILEPTIC RAT, SER) - EXAGGERATION OF CLINICAL AND NEUROPATHOLOGICAL PHENOTYPES IN SER [J].

KONDO, A ;

NAGARA, H ;

AKAZAWA, K ;

TATEISHI, J ;

SERIKAWA, T ;

YAMADA, J .

BRAIN, 1991, 114 :979-999

[7] REGIONAL MAPPING OF THE ROWETT NUDE GENE (RONU) TO RAT CHROMOSOME 10Q24-]Q32 BY LOCALIZING LINKED SYB2 AND GH LOCI [J].

KURAMOTO, T ;

SERIKAWA, T ;

HAYASAKA, N ;

MORI, M ;

YAMADA, J .

CYTOGENETICS AND CELL GENETICS, 1993, 63 (02) :107-110

[8] A STRATEGY FOR RAPID CONSTRUCTION OF GENETIC AND PHYSICAL MAPS IN THE RAT [J].

KURAMOTO, T ;

MORI, M ;

HIRAYAMA, N ;

SABURI, S ;

YAMADA, J ;

SERIKAWA, T .

ACTA HISTOCHEMICA ET CYTOCHEMICA, 1993, 26 (04) :325-332

[9] MOLECULAR-CLONING AND COMPLETE SEQUENCE OF PRION PROTEIN CDNA FROM MOUSE-BRAIN INFECTED WITH THE SCRAPIE AGENT [J].

LOCHT, C ;

CHESEBRO, B ;

RACE, R ;

KEITH, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (17) :6372-6376

[10] GENE-LINK - A PROGRAM IN PASCAL FOR BACKCROSS GENETIC-LINKAGE ANALYSIS [J].

MONTAGUTELLI, X .

JOURNAL OF HEREDITY, 1990, 81 (06) :490-491

← 1 2 3 →