1,25(OH)2-VITAMIN-D(3), A STEROID-HORMONE THAT PRODUCES BIOLOGIC EFFECTS VIA BOTH GENOMIC AND NONGENOMIC PATHWAYS

被引:221
作者
NORMAN, AW
NEMERE, I
ZHOU, LX
BISHOP, JE
LOWE, KE
MAIYAR, AC
COLLINS, ED
TAOKA, T
SERGEEV, I
FARACHCARSON, MC
机构
[1] UNIV CALIF RIVERSIDE,DEPT BIOCHEM,RIVERSIDE,CA 92521
[2] UNIV TEXAS,DENT BRANCH,DEPT BIOL CHEM,HOUSTON,TX 77030
关键词
D O I
10.1016/0960-0760(92)90349-N
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The hormonally active form of vitamin D is 1,25(OH)2-vitamin D3 [1,25(OH)2D3]. This seco-steroid is the key mediator of the vitamin D endocrine system which produces biological effects in over 28 target tissues. In these target tissues, the biological responses may be generated both by a signal transduction mechanism which involves a nuclear receptor for 1,25(OH)2D3 that modulates gene transcription or a signal transduction pathway which involves rapid opening of Ca2+ channels which are externally located on the plasma membrane. This paper reviews the evidence in support of the pleiotropic effects of this steroid hormone and presents evidence that the receptor of the genomic effects is likely to be separate from the receptor/membrane recognition element which initiates the rapid nongenomic biological effects.
引用
收藏
页码:231 / 240
页数:10
相关论文
共 38 条