SYNTHESIS OF 2 2'-DEOXYURIDINE ANALOGS SUBSTITUTED IN POSITION-5 WITH 2-ATOM TETHERED NITROXIDE RADICALS

被引:4
作者
KRYAK, DD [1 ]
BOBST, AM [1 ]
机构
[1] UNIV CINCINNATI,DEPT CHEM,CINCINNATI,OH 45221
来源
NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 08期
基金
美国国家卫生研究院;
关键词
D O I
10.1080/07328319008046059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis of two novel spin labeled 2'-deoxyuridine analogs is described. The nucleic acid building block is substituted in position 5 with a short methylamino tether, which bears either a six- or five-membered nitroxide ring.
引用
收藏
页码:1015 / 1019
页数:5
相关论文
共 12 条
  • [1] BAERWOLFF D, 1973, NUCLEIC ACID CHEM, P359
  • [2] BOBST AM, 1984, J BIOL CHEM, V259, P2130
  • [3] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF C(5)-N-SPIN-LABELED URIDINES AND RELATED DERIVATIVES
    BOBST, AM
    OZINSKAS, AJ
    DECLERCQ, E
    [J]. HELVETICA CHIMICA ACTA, 1983, 66 (02) : 534 - 541
  • [4] REDOX-ACTIVE DAUNOMYCIN SPIN-LABELED NUCLEIC-ACID COMPLEXES
    IRELAND, JC
    PAULY, GT
    BOBST, EV
    BOBST, AM
    [J]. BIOCHEMISTRY, 1986, 25 (22) : 6890 - 6895
  • [5] INTERNAL MOTIONS IN RIBONUCLEIC-ACID DUPLEXES AS DETERMINED BY ELECTRON-SPIN RESONANCE WITH SITE-SPECIFICALLY SPIN-LABELED URIDINES
    KAO, SC
    POLNASZEK, CF
    TOPPIN, CR
    BOBST, AM
    [J]. BIOCHEMISTRY, 1983, 22 (24) : 5563 - 5568
  • [6] LOCAL BASE DYNAMICS AND LOCAL STRUCTURAL FEATURES IN RNA AND DNA DUPLEXES
    KAO, SC
    BOBST, AM
    [J]. BIOCHEMISTRY, 1985, 24 (20) : 5465 - 5469
  • [7] DNA DYNAMICS FROM A SPIN PROBE - DEPENDENCE OF PROBE MOTION ON TETHER LENGTH
    KIRCHNER, JJ
    HUSTEDT, EJ
    ROBINSON, BH
    HOPKINS, PB
    [J]. TETRAHEDRON LETTERS, 1990, 31 (05) : 593 - 596
  • [8] FORMATION OF N-HYDROXY-AMINES OF SPIN LABELED NUCLEOSIDES FOR H-1-NMR - ANALYSIS
    OZINSKAS, AJ
    BOBST, AM
    [J]. HELVETICA CHIMICA ACTA, 1980, 63 (06) : 1407 - 1411
  • [9] A RIGID AND NONPERTURBING PROBE FOR DUPLEX DNA MOTION
    SPALTENSTEIN, A
    ROBINSON, BH
    HOPKINS, PB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (04) : 1299 - 1301
  • [10] SEQUENCE-DEPENDENT AND STRUCTURE-DEPENDENT DNA-BASE DYNAMICS - SYNTHESIS, STRUCTURE, AND DYNAMICS OF SITE AND SEQUENCE SPECIFICALLY SPIN-LABELED DNA
    SPALTENSTEIN, A
    ROBINSON, BH
    HOPKINS, PB
    [J]. BIOCHEMISTRY, 1989, 28 (24) : 9484 - 9495