DNA CROSS-LINKING STUDIES ON FR900482 - OBSERVATIONS ON THE MODE OF ACTIVATION

被引：34

作者：

WILLIAMS, RM

RAJSKI, SR

机构：

[1] Department of Chemistry, Colorado State University Fort Collins

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)79563-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cross-linking of duplex DNA by FR-900482 and its natural reduction product FR-66979 reveals that the parent drug (FR-900482) requires a full equivalent of thiol to effect cross-link formation; FR-66979 requires no reductive activation.

引用

页码：2929 / 2932

页数：4

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