COMPARISON OF THE PATHOGENICITY FOR PREGNANT SHEEP OF RIFT-VALLEY FEVER VIRUS AND A LIVE ATTENUATED VACCINE

被引:24
作者
BASKERVILLE, A [1 ]
HUBBARD, KA [1 ]
STEPHENSON, JR [1 ]
机构
[1] PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV BIOL,SALISBURY SP4 0JG,WILTS,ENGLAND
关键词
D O I
10.1016/0034-5288(92)90029-2
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A live attenuated mutant of Rift Valley fever virus, MV P12, was previously shown to be non-pathogenic in young lambs, but capable of producing protective immunity. The studies reported here show that the abortion in sheep caused by an infection with virulent virus is the result of necrosis of the maternal villi and cotyledons arising from an acute inflammation of the maternal caruncles. Pregnant ewes infected with the attenuated mutant virus MV P12 showed none of these lesions in the placenta and gave birth to healthy lambs. Colostrum from ewes infected with MV P12 virus was able to induce protective immunity in the offspring. These data along with previously published results suggest that the mutant virus MV P12 is an excellent candidate for use as a live attenuated veterinary vaccine.
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页码:307 / 311
页数:5
相关论文
共 12 条
[1]  
BARNARD BJH, 1977, J S AFR VET ASSOC, V48, P45
[2]  
BISHOP DHL, 1979, COMPREHENSIVE VIROLO, V14, P1
[3]   MUTAGEN-DIRECTED ATTENUATION OF RIFT-VALLEY FEVER VIRUS AS A METHOD FOR VACCINE DEVELOPMENT [J].
CAPLEN, H ;
PETERS, CJ ;
BISHOP, DHL .
JOURNAL OF GENERAL VIROLOGY, 1985, 66 (OCT) :2271-2277
[4]  
HUBBARD KA, 1991, AM J VET RES, V52, P50
[5]   EPIZOOTIC OF RIFT VALLEY FEVER IN EGYPT IN 1977 [J].
MEEGAN, JM ;
HOOGSTRAAL, H ;
MOUSSA, MI .
VETERINARY RECORD, 1979, 105 (06) :124-125
[6]  
MORRILL JC, 1987, AM J VET RES, V48, P1042
[7]   FURTHER EVALUATION OF A MUTAGEN-ATTENUATED RIFT-VALLEY FEVER VACCINE IN SHEEP [J].
MORRILL, JC ;
CARPENTER, L ;
TAYLOR, D ;
RAMSBURG, HH ;
QUANCE, J ;
PETERS, CJ .
VACCINE, 1991, 9 (01) :35-41
[8]  
PETERS CJ, 1981, CRC HDB SERIES ZOO B, V1, P403
[9]  
RANDALL R, 1964, J IMMUNOL, V93, P293
[10]  
SMITHBURN KC, 1949, BRIT J EXP PATHOL, V30, P1