LONG-TERM TREATMENT WITH GLUCOCORTICOIDS INCREASES SYNTHESIS AND STABILITY OF JUNCTIONAL ACETYLCHOLINE-RECEPTORS ON INNERVATED CULTURED HUMAN MUSCLE

被引：26

作者：

BRAUN, S ^{[1
]}

ASKANAS, V ^{[1
]}

ENGEL, WK ^{[1
]}

IBRAHIM, EN ^{[1
]}

机构：

[1] UNIV SO CALIF, SCH MED,CTR NEUROMUSC, RON STEVER TISSUE CULTURE LAB,637 S LUCAS AVE, LOS ANGELES, CA 90017 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 60卷 / 05期

关键词：

INNERVATED CULTURED HUMAN MUSCLE; ACETYLCHOLINE RECEPTORS; GLUCOCORTICOIDS;

D O I：

10.1111/j.1471-4159.1993.tb13422.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We have studied the effect of long-term treatment with hydrocortisone on the expression of acetylcholine receptors (AChRs) at the neuromuscular junctions of human muscle cultured in monolayer and innervated de novo by fetal rat spinal cord motoneurons. Hydrocortisone increased accumulation of junctional AChRs in a dose- and time-dependent fashion. This increase was due to both decreased degradation and increased synthesis of AChRs. Other glucocorticoids, dexamethasone and prednisolone, exerted similar effects. Our study demonstrates a novel action of glucocorticoids on human junctional AChRs.

引用

页码：1929 / 1935

页数：7

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