MULTIPLE CYTOKINE MESSENGER-RNA EXPRESSION IN HUMAN MAST-CELLS STIMULATED VIA FC-EPSILON-RI

被引：36

作者：

OKAYAMA, Y ^{[1
]}

SEMPER, A ^{[1
]}

HOLGATE, ST ^{[1
]}

CHURCH, MK ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,IMMUNOPHARMACOL GRP,SOUTHAMPTON,HANTS,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

HUMAN MAST CELLS; CYTOKINE; FC-EPSILON-RI;

D O I：

10.1159/000236963

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cross-linkage of Fc epsilon RI on human lung mast cells purified by affinity magnetic selection with monoclonal antibody YB5.B8 against c-kit (purity > 90%) expressed mRNA for multiple cytokines. There was no constitutive expression of interleukin (IL)-4 mRNA. Mast cell stimulation with anti-IgE induced IL-4 mRNA expression which appeared maxmal at 2 h and waned slowly over the next 24 h. IL-5, IL-6, IL-8 and tumour necrosis factor (TNF)-alpha mRNA were constitutively expressed. Mast cell activation with anti-IgE led to an increase of IL-5 and TNF-alpha m RNA signals within 2 h and which persisted for at least 24-48 h. On the other hand, IL-S and IL-8 mRNA expression were not affected by anti-IgE challenge.

引用

页码：158 / 159

页数：2

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