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A NEW ANIMAL-MODEL OF CEREBRAL INFARCTION - MAGNETIC EMBOLIZATION WITH CARBONYL IRON PARTICLES

被引：5
作者：
AKAI, F
MAEDA, M
HASHIMOTO, S
TANEDA, M
TAKAGI, H
机构：
[1] OSAKA CITY UNIV,SCH MED,DEPT ANAT 1,ABENO KU,OSAKA 545,JAPAN
[2] KINKI UNIV,SCH MED,DEPT NEUROSURG,OSAKA 589,JAPAN
[3] KINKI UNIV,SCH MED,DEPT PATHOL 2,OSAKA 589,JAPAN
来源：
NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期
关键词：
CEREBRAL INFARCTION; ANIMAL MODEL; IRON PARTICLES; EMBOLI; ELECTROMAGNET; MONGOLIAN GERBIL;
D O I：
10.1016/0304-3940(95)11738-I
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A new animal model of cerebral infarction was developed by magnetic embolization with carbonyl iron particles. An electromagnet was placed upon the lateral portion outside the orbit of Mongolian gerbils and charged with a current intensity of 2 A, 3 V (400 G) for 10 min. By intracardiac injection of iron particles at the beginning of the electric charge, infarction was selectively produced in the cerebral cortex. Two days after the operation, microhemorrhaging was seen in the necrotic region. Multiple scattered infarctions accompanied with microhemonhagic signs closely resembled embolic infarction encountered in the human brain.
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页码：139 / 141
页数：3
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