GENETIC CHANGES DURING MOUSE SKIN TUMORIGENESIS

被引：13

作者：

BURNS, PA

BREMNER, R

BALMAIN, A

机构：

来源：

ENVIRONMENTAL HEALTH PERSPECTIVES | 1991年 / 93卷

关键词：

D O I：

10.2307/3431166

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This paper describes specific genetic changes involving chromosome 7 in mouse skin tumors, the most important consequence of which appears to be an alteration in the allelic balance of normal and mutant H-ras genes. The use of restriction-fragment-length polymorphisms in F1 hybrid mice demonstrates that trisomy of chromosome 7 is an early event preceding papilloma formation, and further events, such as mitotic recombination, seem to occur during progression to malignant carcinomas. There is some evidence of a tumor-suppressor locus situated on chromosome 7.

引用

收藏

页码：41 / 44

页数：4

相关论文

共 18 条

[1] SEQUENTIAL TRISOMIZATION OF CHROMOSOME-6 AND CHROMOSOME-7 IN MOUSE SKIN PREMALIGNANT LESIONS [J].

ALDAZ, CM ;

TRONO, D ;

LARCHER, F ;

SLAGA, TJ ;

CONTI, CJ .

MOLECULAR CARCINOGENESIS, 1989, 2 (01) :22-26

[2] PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS [J].

BOS, JL ;

FEARON, ER ;

HAMILTON, SR ;

VERLAANDEVRIES, M ;

VANBOOM, JH ;

VANDEREB, AJ ;

VOGELSTEIN, B .

NATURE, 1987, 327 (6120) :293-297

[3] GENETIC CHANGES IN SKIN TUMOR PROGRESSION - CORRELATION BETWEEN PRESENCE OF A MUTANT RAS GENE AND LOSS OF HETEROZYGOSITY ON MOUSE CHROMOSOME-7 [J].

BREMNER, R ;

BALMAIN, A .

CELL, 1990, 61 (03) :407-417

[4] V-RAS GENES FROM HARVEY AND BALB MURINE SARCOMA-VIRUSES CAN ACT AS INITIATORS OF 2-STAGE MOUSE SKIN CARCINOGENESIS [J].

BROWN, K ;

QUINTANILLA, M ;

RAMSDEN, M ;

KERR, IB ;

YOUNG, S ;

BALMAIN, A .

CELL, 1986, 46 (03) :447-456

[5] CARCINOGEN-INDUCED MUTATIONS IN THE MOUSE C-HA-RAS GENE PROVIDE EVIDENCE OF MULTIPLE PATHWAYS FOR TUMOR PROGRESSION [J].

BROWN, K ;

BUCHMANN, A ;

BALMAIN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :538-542

[6] TUMORIGENIC TRANSFORMATION OF MAMMALIAN-CELLS INDUCED BY A NORMAL HUMAN-GENE HOMOLOGOUS TO THE ONCOGENE OF HARVEY MURINE SARCOMA-VIRUS [J].

CHANG, EH ;

FURTH, ME ;

SCOLNICK, EM ;

LOWY, DR .

NATURE, 1982, 297 (5866) :479-483

[7]

DIPPLE A, 1983, CANCER RES, V43, P4132

[8] TUMOR PROMOTER 12-O-TETRADECANOYL-PHORBOL-13-ACETATE ENHANCES SISTER CHROMATID EXCHANGES AND NUMERICAL AND STRUCTURAL CHROMOSOME-ABERRATIONS IN PRIMARY MOUSE EPIDERMAL-CELL CULTURES [J].

DZARLIEVA, RT ;

FUSENIG, NE .

CANCER LETTERS, 1982, 16 (01) :7-17

[9] A RAS-RELATED GENE WITH TRANSFORMATION SUPPRESSOR ACTIVITY [J].

KITAYAMA, H ;

SUGIMOTO, Y ;

MATSUZAKI, T ;

IKAWA, Y ;

NODA, M .

CELL, 1989, 56 (01) :77-84

[10] LOSS OF ALLELES AT LOCI ON HUMAN CHROMOSOME-11 DURING GENESIS OF WILMS TUMOR [J].

KOUFOS, A ;

HANSEN, MF ;

LAMPKIN, BC ;

WORKMAN, ML ;

COPELAND, NG ;

JENKINS, NA ;

CAVENEE, WK .

NATURE, 1984, 309 (5964) :170-172