DOPAMINERGIC REGULATION OF CORTICAL ACETYLCHOLINE-RELEASE

被引:107
作者
DAY, J [1 ]
FIBIGER, HC [1 ]
机构
[1] UNIV BRITISH COLUMBIA, DEPT PSYCHIAT, DIV NEUROL SCI, 2255 WESBROOK MALL, VANCOUVER V6T 1Z3, BC, CANADA
关键词
AMPHETAMINE; APOMORPHINE; CORTEX; DOPAMINE; HALOPERIDOL; MICRODIALYSIS; RACLOPRIDE; SCH-23390;
D O I
10.1002/syn.890120405
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The extent to which the activity of basal forebrain cholinergic neurons is influenced by dopamine (DA) was investigated using in vivo microdialysis of cortical acetylcholine (ACh). Systemic administration of the DA receptor agonist apomorphine significantly increased dialysate concentrations of ACh. Systemic, but not local, administration of d-amphetamine produced similar effects. Both D1 (SCH 23390) and D2 (haloperidol, raclopride) DA receptor antagonists attenuated the amphetamine-induced increase in cortical ACh release; however, only the D1 antagonist significantly reduced basal output of cortical ACh. These findings suggest that the activity of cortically projecting cholinergic neurons in the nucleus basalis is regulated in an excitatory manner by central dopaminergic neurons and that both D1 and D2 receptors are involved.
引用
收藏
页码:281 / 286
页数:6
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