HUMAN CARDIAC ALLOGRAFT-REJECTION - CORRELATION OF GRADING WITH EXPRESSION OF DIFFERENT MONOCYTE MACROPHAGE MARKERS

被引：21

作者：

GASSEL, AM ^{[1
]}

HANSMANN, ML ^{[1
]}

RADZUN, HJ ^{[1
]}

WEYAND, M ^{[1
]}

机构：

[1] UNIV KIEL,MED CTR,DEPT CARDIOVASC SURG,W-2300 KIEL 1,GERMANY

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1990年 / 94卷 / 03期

关键词：

cardiac allograft rejection; monoclonal antibodies; monocytes/macrophages;

D O I：

10.1093/ajcp/94.3.274

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Endomyocardial biopsies from human cardiac allografts were investigated with the use of immunohistochemical methods. A correlation between the different degrees of rejection reaction and subtypes of monocyte/macrophage infiltrates was established. Early and mild rejection is characterized by recently immigrated monocytes/macrophages positive for the monoclonal antibody Ki-M1. In contrast, the cellular infiltrates in severe and resolving rejection show strong expression of antigens recognized by Ki-M6 and Ki-M8, indicating increased phagocytotic function of monocytes/macrophages. The immunohistochemical assessment of monocytes/macrophages can thus be used, in addition to conventional histology, in the diagnosis of cardiac allograft rejection.

引用

页码：274 / 279

页数：6

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