MULTIPLE-COLUMN SOLID-PHASE GLYCOPEPTIDE SYNTHESIS

被引：65

作者：

PETERS, S ^{[1
]}

BIELFELDT, T ^{[1
]}

MELDAL, M ^{[1
]}

BOCK, K ^{[1
]}

PAULSEN, H ^{[1
]}

机构：

[1] CARLSBERG LAB,DEPT CHEM,DK-2500 COPENHAGEN,DENMARK

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 09期

关键词：

D O I：

10.1039/p19920001163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the two new building blocks N(alpha)-Fmoc-Ser(Ac3-alpha-D-GalpNAc)-OPfp 6 and N(alpha)-Fmoc-Thr(Ac3-alpha-D-GalpNAc)-OPfp 7 and their application in a simultaneous multiple-column solid-phase synthesis of 40 different O-glycopeptides from human intestinal mucin and porcine submaxillary gland mucin are described. All glycopeptides were obtained in excellent purity and were characterised by 1D- and 2D-H-1 NMR spectroscopy and amino acid analyses.

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页码：1163 / 1171

页数：9

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